Reference R-Genes, manually curated

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Plant resistance genes ( R-genes) encode proteins involved in resistance mechanisms that directly or indirectly recognize pathogen effectors. Different Models for R-gene activation.


(Li Y, Tessaro MJ, Li X, Zhang Y. Regulation of the expression of plant resistance gene SNC1 by a protein with a conserved BAT2 domain. Plant Physiol. 2010 Jul;153(3):1425-34 PMID:20439546)

R-genes have been isolated from a variety of plants. R-genes encode for resistance proteins (R-proteins), a class of proteins that activate signaling cascade to promote the initial plant defense responses to impair pathogen devlopment. R-proteins would be expressed in healthy plants to ready detect an external attack. R-proteins are characterized by rapid evolution of specificity, a mechanism leading to an effective response to the regular evolution of pathogens and resist to new virulent pathogens.

(Hammond-Kosack KE, Jones JD.PLANT DISEASE RESISTANCE GENES. Annu Rev Plant Physiol Plant Mol Biol. 1997 Jun;48:575-607. PMID:15012275)


Generally, R-genes share homologous functional domains and can occur either as isolated genes or (as commonly occurs) as tandem clusters.

(de Meaux J, Mitchell-Olds T. Evolution of plant resistance at the molecular level: ecological context of species interactions. Heredity (Edinb). 2003 Oct;91(4):345-52. PMID:14512948)

In PRG database is published a R-gene list

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